1. Home
  2. Vol 10, No 2 (2024)
  3. Chohan

Efektivitas Suplementasi Zinc Terhadap Pasien Anak dengan Pneumonia

DOI: 10.29241/jmk.v10i2.1945

Author

Shania Chohan(1*), Yessi Crosita Octaria(2)

(1) Universitas Pembangunan Nasional Veteran Jakarta
(2) Universitas Pembangunan Nasional Veteran Jakarta
(1*) Corresponding Author

Full Text

Full Text: View / Download PDF

Article Metrics

Abstract View : 214 times; PDF Download : 52 times

Abstract

Pneumonia adalah salah satu penyebab utama morbiditas dan mortalitas pada anak di bawah 5 tahun. Mikronutrien, termasuk zinc, penting untuk pertahanan tubuh terhadap penyakit menular dan kesehatan sistem kekebalan tubuh. Zinc memiliki fungsi imunomodulator yang menjadikannya agen terapi potensial dalam pengobatan pneumonia. Penelitian ini bertujuan menganalisis efektivitas suplementasi zinc terhadap sistem imun pada anak-anak dengan pneumonia melalui tinjauan literatur sistematis. Penelitian ini menggunakan metode Systematic Literature Review (SLR) yang dilakukan pada Juni 2024, mengikuti pedoman PRISMA dengan fokus pada Randomized Controlled Trials (RCT). Hasil tinjauan menunjukkan bahwa suplementasi zinc secara signifikan efektif dalam mengurangi durasi efusi pleura, mempercepat normalisasi tingkat saturasi oksigen, menurunkan demam, dan menormalkan laju pernapasan. Data literatur diperoleh dari PubMed Central, Google Scholar, PLOS, Cochrane Library, dan Oxford Academy dengan batasan waktu 2019-2024. Dari 2.416 artikel yang ditemukan, sembilan artikel memenuhi kriteria inklusi setelah seleksi bertahap. Artikel-artikel ini dianalisis untuk menemukan persamaan, perbedaan, dan kesimpulan mengenai efektivitas zinc dalam pengobatan pneumonia pada anak-anak. Penelitian ini menyimpulkan bahwa zinc berdampak positif pada sistem imun anak dengan pneumonia, mengurangi gejala, dan durasi rawat inap.


Keywords

Suplementasi, zinc, sistem imun, pneumonia, anak.

References

Afolami, I. (2021). Efficacy of biofortified (yellow) cassava on serum retinol in pre-school Nigerian children. Wageningen University and Research. Ahmed, A. F., Sufian, A., Hossain, A., & Majumder, R. C. (2022). Adjuvant zinc therapy helps in early normalization of hospitalized patient (children) suffering from pneumonia. Mainamoti Medical College, 33. Ahmed, A. T. M. F., Hyder, R. T., Sufian, A., Hossain., & Majumder. (2021). Potential Effect of Zinc in Disappearance of Fever in Severe Pneumonia in Children. Army Medical College Cumilla Journal, 4(2). Al-juboory, A. F. R., & Alnassrawi, L. A. H. (2022). Effect of Zinc Sulphate as Adjuvant Therapy in the Treatment of Severe Pneumonia in Children Aged Under 2 years. Academic Journal of Medical Sciences. Atta, A., Aftab, A., Shafqat, A., Yousuf, M. H., Ahmed, A., Pirzada, H., Khalid, H., & Hastings, N. E. (2024). Investigating the Efficacy of Zinc and Vitamin A in Treating Pediatric Community-Acquired Pneumonia. Cureus, 16(1).
https://doi.org/10.7759/cureus.52197 Gammoh, N. Z., & Rink, L. (2017). Zinc in infection and inflammation. Nutrients, 9(6), 624.
https://doi.org/10.3390/nu9060624 Hashemian, H., Alizadeh, H., & Leyli, E. K. (2021). Efficacy of zinc as adjuvant therapy in the treatment of severe pneumonia in hospitalized children: a randomized clinical trial. Archives of Pediatric Infectious Diseases, 9(1).
https://doi.org/10.5812/pedinfect.105318 Heydarian, F., Nasiri, M., Attaei Nakhaie, A. R., Ahanchian, H., Ghahremani, S., Haghbin, A., & Ghahremani, S. (2020). Investigating the effect of prescribing zinc sulfate on improving the clinical symptoms of pneumonia in 2-59-month-old children. International Journal of Pediatrics, 8(11), 12471-12479. Hunter, J., Arentz, S., Goldenberg, J., Yang, G., Beardsley, J., Mertz, D., & Leeder, S. (2021). Corrigendum to "Rapid review protocol: Zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections" [Integr Med Res 9 (2020): 100457]. Integrative Medicine Research, 10(1).
https://doi.org/10.1016/j.imr.2020.100689 Hunter, J., Arentz, S., Goldenberg, J., Yang, G., Beardsley, J., Myers, S. P., Mertz, D., & Leeder, S. (2021). Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and meta-analysis of randomised controlled trials. BMJ Open, 11(11).
https://doi.org/10.1136/bmjopen-2020-047474 Kementerian Kesehatan RI. (2023). Rencana aksi nasional penanggulangan pneumonia di indonesia 2023-2030. In Kementrian Kesehatan. Kuti, B. P., Adetola, H. H., & Oyelami, O. A. (2021). Serum micronutrients as related to childhood pneumonia severity and outcome in a Nigerian health facility. The Journal of Infection in Developing Countries, 15(7), 953-961.
https://doi.org/10.3855/jidc.13792 Laghari, G. S., Hussain, Z., Taimur, M., & Jamil, N. (2019). Therapeutic role of zinc supplementation in children hospitalized with pneumonia. Cureus, 11(4).
https://doi.org/10.7759/cureus.4475 Prasad, A. S. (2017). Discovery of zinc for human health and biomarkers of zinc deficiency. In Molecular, genetic, and nutritional aspects of major and trace minerals. Academic Press.
https://doi.org/10.1016/B978-0-12-802168-2.00020-8 Read, S. A., Obeid, S., Ahlenstiel, C., & Ahlenstiel, G. (2019). The role of zinc in antiviral immunity. Advances in Nutrition, 10(4), 696-710.
https://doi.org/10.1093/advances/nmz013 Rerksuppaphol, L., & Rerksuppaphol, S. (2020). Efficacy of adjunctive zinc in improving the treatment outcomes in hospitalized children with pneumonia: a randomized controlled trial. Journal of Tropical Pediatrics, 66(4), 419-427.
https://doi.org/10.1093/tropej/fmz082 Saied, A., El Borolossy, R. M., Ramzy, M. A., & Sabri, N. A. (2022). Effect of zinc versus v itamin A supplementation on pediatric patients with community-acquired pneumonia. Frontiers in Pharmacology, 13.
https://doi.org/10.3389/fphar.2022.933998 Skalny, A. V., Rink, L., Ajsuvakova, O. P., Achner, M., Gritsenko, V. A., Alekseenko, S. I., & Tinkov, A. A. (2020). Zinc and respiratory tract infections: Perspectives for COVID-19. International Journal of Molecular Medicine, 46(1), 17-26.
https://doi.org/10.3892/ijmm.2020.4575 Wildani, D. A. Z. P., Putri, M., & Risanti, R. (2022). Suplementasi Zinc dalam Penyembuhan Gejala Pneumonia pada Anak. In Bandung Conference Series: Medical Science, 2(1), 857-866. Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020). Angiotensin- converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanism and potential therapeutic target. Intensive Care Medicine, 46, 586-590.
https://doi.org/10.1007/s00134-020-05985-9

Refbacks

  • There are currently no refbacks.




Copyright (c) 2024 Shania Chohan, Yessi Crosita Octaria

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.